Abstract
Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host–pathogen interactions and identifying chief factors involved in host defense and pathogen virulence in Drosophila serves as a foundation to establish novel strategies for infectious disease prevention and control in higher organisms, including humans.
Highlights
Drosophila, a chief tool in contemporary genetic studies, became one of the most powerful model organisms widely used in scientific explorations
Further studies conducted in Drosophila have contributed to novel groundbreaking findings that allowed the identification of fundamental components of different pathways conserved between the fruit fly and higher mammalian organisms, including humans
We provide an overview of the use of Drosophila in host–pathogen interaction studies and highlight the role of the fly’s innate immune system in pathogen control
Summary
Drosophila, a chief tool in contemporary genetic studies, became one of the most powerful model organisms widely used in scientific explorations. Humoral innate immune responses in Drosophila mainly include production of AMPs and anti-pathogenic factors through Toll, IMD, and JAK/STAT signaling pathways.
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