Droperidol or Olanzapine, Intramuscularly or Intravenously, Monotherapy or Combination Therapy for Sedating Acute Behavioral Disturbance

Abstract

SEE RELATED ARTICLES, P. 318 AND 327. A Prospective Observational Study of Patients Receiving Intravenous and Intramuscular Olanzapine in the Emergency DepartmentAnnals of Emergency MedicineVol. 69Issue 3PreviewParenteral olanzapine is an emerging therapy for a variety of conditions in the emergency department (ED). Intramuscular administration is standard; however, intravenous administration has been proposed as a safe alternative route. We investigate the safety and efficacy of both intramuscular and intravenous olanzapine in the ED when used for a variety of indications. Full-Text PDF Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical TrialAnnals of Emergency MedicineVol. 69Issue 3PreviewWe aim to determine the most efficacious of 3 common medication regimens for the sedation of acutely agitated emergency department (ED) patients. Full-Text PDF The “Appropriate” Use of Olanzapine in the Emergency DepartmentAnnals of Emergency MedicineVol. 69Issue 6PreviewWe read with great interest Dr. Isbister’s recent editorial,1 which includes commentary on our recent article.2 We agree that olanzapine is a reasonable alternative for acutely agitated patients when droperidol is unavailable. Full-Text PDF Treatment Goal for Agitation: Sedation or CalmingAnnals of Emergency MedicineVol. 70Issue 5PreviewAnnals recently published a series of articles comparing different drugs in the treatment of agitation. These articles stipulate that the goal of treating agitated patients in the emergency department (ED) is to sedate them because, in the words of Isbister,1 “sedating them and controlling the situation is essential to everyone’s safety.” Full-Text PDF