Abstract
Dronedarone is a class III antiarrhythmic drug. Another class III drug, amiodarone, is currently the most commonly used antiarrhythmic drug for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). However, its use is complicated by toxicities and complex dosing. Dronedarone is a structural derivative of amiodarone developed to provide a safer alternative. The efficacy of dronedarone has been demonstrated in patients with paroxysmal or persistent AF. A recent trial was conducted to determine whether these benefits extend to patients with permanent AF. This article will discuss the implications of this trial and the evolving role of dronedarone in the management of AF.
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