Abstract
• d -Galactose-induced aging exacerbated aging markers such as serum malondialdehyde (MDA), advanced glycation end product (AGE) and liver MDA level. d -Galactose injection led to inactivation of phosphoinositide 3-kinase (PI3K) pathway which resulted in decrease of nuclear factor-erythroid 2-related factor 2 (Nrf2) and increase of nuclear factor-kappa B (Nf-κB) protein expression in liver. Our results showed that decreased protein expression of Nrf2, with increase in KEAP1 expression, led to decrease in catalase (CAT) and superoxide dismutase 2 (SOD2) protein expression in liver.
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