Abstract
Background and Aim:In the male reproductive system, the aging process can lead to infertility. Recently, placenta and its derivatives have been researched as regenerative agents. This study aimed to describe the basic components of dried bovine placenta powder and its potential effects as a regenerative agent in a rat model of male reproductive aging with D-galactose induction.Materials and Methods:We divided 15 male Wistar rats, 2 months of age, into three groups: A, the health control group; B, the D-galactose induction group, and C, the D-galactose induction and 10% dried bovine placenta supplementation group. We measured epididymal sperm concentration and testicular weight and volume and analyzed these using one-way analysis of variance.Results:Dried bovine placenta was rich in nutrients, with 61.98% protein, 21.25±2.07 carbohydrates, 8.58% water, 4.93% ash, and 3.27% fat. The mean epididymal spermatozoa concentration of the rats in Groups A, B, and C was 3026×106/mL, 1492.8×106/mL, and 2732.5×106/mL, respectively. The average total testicle weights were 2.44 g, 2.72 g, and 2.57 g, respectively. The average total testicle volumes were 2.29 cm3, 2.49 cm3, and 2.33cm3, respectively.Conclusion:Dried bovine placenta powder is rich in nutrients, especially protein. Supplementation with dried bovine placenta can improve epididymal spermatozoa concentration that is important in fertility.
Highlights
Aging is a complex biological process involving organic, cellular, and molecular changes
Dried bovine placenta powder is rich in nutrients, especially protein
Supplementation with dried bovine placenta can improve epididymal spermatozoa concentration that is important in fertility
Summary
Aging is a complex biological process involving organic, cellular, and molecular changes. This process is caused chronologically by increasing age but can be accelerated by environmental factors that cause oxidative stress [1,2]. In the male reproductive system, the aging process can lead to infertility. Supplementation to improve bull reproductive performance is an option, but it has not been done because limited research exists on regenerative agents for male livestock reproductive degeneration caused by aging. This study aimed to describe the basic components of dried bovine placenta powder and its potential effects as a regenerative agent in a rat model of male reproductive aging with D-galactose induction
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