Abstract
The experiments herein reported were undertaken as a preliminary investigation of the problem of the possible efficacy of Dreyer's tubercle antigen in the treatment of guinea-pigs infected with tuberculosis. It was planned to continue the experiments on a larger scale, using a much greater number of animals inoculated with material of varying grades of infectivity, and employing an adequate series of controls. The result of this preliminary study was so discouraging, however, that it was not felt that the labor and expense of an elaborate investigation would be justified. Dreyer's paper attracted considerable attention and yet there has been a great paucity of either confirmatory or contradictory reports by other workers; because of this it was felt that our negative results should be recorded. Dreyer, 1 in 1923, asserted that, as a general rule, most of the failures in vaccine therapy have been with the acid-fast and the gram-positive organisms. Since
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