DRESS syndrome due to Anti-Tuberculous Drug

Abstract

DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) is a potentially life threatening syndrome caused by exposureto certain medications. That may cause skin rash, fever, inflammation of internal organs, lymphadenopathy, and characteristichematologic abdnormalities such ad eosinophilia, thrombocytopenia, and typical atypical lymphocytosis. The interval between thestarting of drug therapy and the onset of cutaneous reactions may be at least one month. Aromatic anticonvulsants(phenytoin, phenobarbital, carbamazepine) and sulfonamides are the most common causes of DRESS. There has been only afew case reports of DRESS syndrome induced by anti-tuberculous medication, Ethambutol, Rifampin, Isoniazid, Pyrazinamide. Wereport a case of Ethambutol induced DRESS syndrome and multiple drug hypersensitivity to other antituberculosis drugs thatwere used at after DRESS syndrome developed.