Abstract
DNA repair mechanisms act as a warrior combating various damaging processes that ensue critical malignancies. DREMECELS was designed considering the malignancies with frequent alterations in DNA repair pathways, that is, colorectal and endometrial cancers, associated with Lynch syndrome (also known as HNPCC). Since lynch syndrome carries high risk (~40–60%) for both cancers, therefore we decided to cover all three diseases in this portal. Although a large population is presently affected by these malignancies, many resources are available for various cancer types but no database archives information on the genes specifically for only these cancers and disorders. The database contains 156 genes and two repair mechanisms, base excision repair (BER) and mismatch repair (MMR). Other parameters include some of the regulatory processes that have roles in these disease progressions due to incompetent repair mechanisms, specifically BER and MMR. However, our unique database mainly provides qualitative and quantitative information on these cancer types along with methylation, drug sensitivity, miRNAs, copy number variation (CNV) and somatic mutations data. This database would serve the scientific community by providing integrated information on these disease types, thus sustaining diagnostic and therapeutic processes. This repository would serve as an excellent accompaniment for researchers and biomedical professionals and facilitate in understanding such critical diseases. DREMECELS is publicly available at http://www.bioinfoindia.org/dremecels.
Highlights
DNA repair mechanisms are regulatory bioprocesses through which a cell) identifies and corrects damages in the DNA, which is necessary for maintaining genome integrity
Studies have revealed that defective mismatch repair (MMR) and base excision repair (BER) mechanisms are involved in many cancers, while their major role has been reported in two disease covered in this study [2,3,4]
DREMECELS is a collection of 156 DNA repair (MMR and BER) genes associated with diseases
Summary
DNA repair mechanisms are regulatory bioprocesses through which a cell) identifies and corrects damages in the DNA, which is necessary for maintaining genome integrity. Numerous studies including expression arrays [9], miRNA arrays [10], comparative genome hybridisation arrays [11], chip-on-chip [12], methylation arrays, mutation analysis, genome-wide association studies, proteomics analysis, integrated functional genomics analysis and related bioinformatics, and biostatistical analysis have been conducted for the genes that get altered in these cancers and in LS [13]. These in-vitro and in-silico techniques provide bulk data regarding cancerrelated genes, which facilitate researchers in deciphering the mechanisms underlying disease progression
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