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Abstract
Cultural studies of a fatal disease of unknown origin with severe neurological symptoms in a human led to the isolation of Drechslera hawaiiensis from the base of the brain. In histological sections abundant, dematiaceous, septate mycelial elements were present. Animals were successfully infected with the isolate, lesions developing in the liver and spleen of mice and the testes of guinea-pigs. Experimental infections were also produced in animals with 6 plant isolates of D. hawaiiensis. The genus Drechslera can be differentiated from the superficially similar genera Bipolaris and Helminthosporium by its conidiophore development.
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