Abstract
Researchers at the National Hospital, Queen Square, Great Ormond Street Hospital, and other centers in the UK and Melbourne, Australia identified a series of 22 adult patients (median age 39 years; range 20-66), including 3 post-mortem cases with Dravet syndrome.
Highlights
Researchers at the National Hospital, Queen Square, Great Ormond Street Hospital, and other centers in the UK and Melbourne, Australia identified a series of 22 adult patients, including 3 post-mortem cases with Dravet syndrome
A family history of epilepsy and/or febrile seizures was present in 9 (41%) adult patients
Testing for SCN1A mutations and the diagnosis of Dravet syndrome should be considered in adults with a long history of seizures resistant to anticonvulsant therapy and fever sensitivity
Summary
Researchers at the National Hospital, Queen Square, Great Ormond Street Hospital, and other centers in the UK and Melbourne, Australia identified a series of 22 adult patients (median age 39 years; range 20-66), including 3 post-mortem cases with Dravet syndrome. SCN1A mutations were found in 12 (60%) of 20 adult patients, novel in 11. A family history of epilepsy and/or febrile seizures was present in 9 (41%) adult patients. Seizure onset in infancy was triggered by vaccination in 11 (41%) cases, pertussis or triple vaccine.
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