Drag-reducing polyethylene oxide improves microcirculation after hemorrhagic shock

Abstract

BackgroundDespite resuscitation after trauma, microcirculatory abnormalities are known to persist in post-shock multiorgan dysfunction. The high-molecular weight polymer polyethylene oxide (PEO) (>106 Da), a classic drag-reducing polymer, can improve hemorrhagic shock (HS)–induced hemodynamic abnormalities in rats. Materials and methodsWe examined the effects of PEO on microcirculation and on changes in multiple organs after shock. After the spinotrapezius muscle was prepared, HS was induced in Sprague–Dawley rats. Drug administration (normal saline or PEO) was performed 2 h after shock followed by infusion of shed blood. ResultsThe velocity, blood flow, and functional capillary density in the shock + PEO group were significantly higher than those in the shock + normal saline group. Moreover, the kidney, liver, and lung function was improved, resulting in prolonged survival time. Our findings indicate that intravenous infusion of PEO can ameliorate shock-associated organ dysfunction and prolong survival time in severe HS, which may be a result of increased arteriolar blood velocity, blood flow, and functional capillary density. ConclusionsPEO could have potential clinical application in the treatment of shock-induced multiorgan dysfunction.