Abstract
Here, we report the draft genome sequences of two methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates, hospital-associated perirectal isolate 32S (ST 239) from a colitis tracheostomy patient and community-associated MRSA isolate 42S (ST 772) from a hepatic-splenomegaly patient in Rawalpindi, Pakistan.
Highlights
Staphylococcus aureus is one of the leading human pathogens that causes a broad variety of infections, ranging from minor skin infections to life-threatening conditions, such as endocarditis, pneumonia, toxic shock syndrome, and bloodstream infections [1,2,3]
Molecular characterization of the virulence and antimicrobial resistance gene profiles and the draft genome sequences of methicillin-resistant S. aureus (MRSA) isolates will enhance the understanding of their evolution and aid in rapid diagnosis, detection, and development of better therapeutic intervention strategies
Views presented in this paper do not necessarily reflect those of the FDA
Summary
Staphylococcus aureus is one of the leading human pathogens that causes a broad variety of infections, ranging from minor skin infections to life-threatening conditions, such as endocarditis, pneumonia, toxic shock syndrome, and bloodstream infections [1,2,3]. Molecular characterization of the virulence and antimicrobial resistance gene profiles and the draft genome sequences of methicillin-resistant S. aureus (MRSA) isolates will enhance the understanding of their evolution and aid in rapid diagnosis, detection, and development of better therapeutic intervention strategies. The isolates described here were highly resistant to oxacillin (MIC, 512 mg/L) and ciprofloxacin (MIC, Ͼ256 mg/L), and exhibited resistance to ampicillin, tetracycline, penicillin, erythromycin, gentamicin, and kanamycin.
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