Abstract
Nontypeable Haemophilus influenzae is an important cause of human disease. Strains were selected for genome sequencing to represent the breadth of nontypeable strains within the species, as previously defined by the electrophoretic mobility of 16 metabolic enzymes.
Highlights
Nontypeable Haemophilus influenzae is an important cause of human disease
To facilitate ongoing studies to identify potential vaccine components, we genomically sequenced selected Nontypeable Haemophilus influenzae (NTHi) isolates from a collection previously characterized by the electrophoretic mobility of 16 metabolic enzymes and presumed to represent the breadth of the species [4, 5]
Samples were indexed according to standard protocols so that they could be pooled together and sequenced simultaneously in a single run on the Illumina MiSeq using paired-end 150-bp (300-cycle; strains HI1373, HI1374, HI1388, HI1394, HI1408, HI1417, and HI1426) or paired-end 250-bp (500-cycle; strain HI1413) chemistry
Summary
Nontypeable Haemophilus influenzae is an important cause of human disease. Strains were selected for genome sequencing to represent the breadth of nontypeable strains within the species, as previously defined by the electrophoretic mobility of 16 metabolic enzymes. Nontypeable Haemophilus influenzae (NTHi) colonizes the human nasopharynx and is an opportunistic pathogen causing significant human disease. NTHi causes both mucosal and invasive infections, including otitis media, exacerbations of chronic obstructive pulmonary disease, and bacteremia [1,2,3].
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