Abstract
Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.
Highlights
We report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates
We have previously described a number of substituted imidazo[1,2-b][1,2,4,5]tetrazines that showed promising MICs against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains
We were able to obtain M. smegmatis mc[2 155] spontaneous mutants that were resistant to 4 different imidazo[1,2b][1,2,4,5]tetrazines at 3.5 to 4ϫ MIC
Summary
We report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates.
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