Abstract
A new strain of Streptomyces sp., strain RFCAC02, was isolated from the gut of the Pacific chub mackerel Scomber japonicus peruanus This strain produces a variety of secondary metabolites. Further bioinformatic analysis revealed the presence of biosynthetic gene clusters putatively coding for compounds related to the polycyclic tetramate macrolactams (PTMs).
Highlights
The uncontrolled use of antibiotics has created conditions for the emergence of multidrug-resistant pathogenic microorganisms, which is challenging health systems worldwide
Pairwise genome comparison confirmed a close relationship between strain RFCAC02 and S. avicenniae MCCC 1A01535, showing an average nucleotide identity (ANI) of 80.58%, a value below the accepted cutoff threshold for species delimitation of 95% [14]
An antiSMASH v4.0 search [15] revealed the presence of 20 putative biosynthetic gene clusters, including clusters coding for the production of polycyclic tetramate macrolactams (PTMs)
Summary
The uncontrolled use of antibiotics has created conditions for the emergence of multidrug-resistant pathogenic microorganisms, which is challenging health systems worldwide. With an average length of 7,011 bp.
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