Abstract
ABSTRACTStrain DH-12 exhibits broad-spectrum antibacterial activity toward Gram-positive and Gram-negative pathogens. The 7.6-Mb draft genome sequence gives insight into the complete secondary metabolite production capacity and reveals genes putatively responsible for its antibacterial activity, as well as genes which enable the survival of the organism in an extreme arid environment.
Highlights
Strain DH-12 exhibits broad-spectrum antibacterial activity toward Grampositive and Gram-negative pathogens
The closest related type strains based on the 16S rRNA gene sequence are Streptomyces xylophagus NBRC 13845 (GenBank accession number AB184526), Streptomyces variabilis NRRL B-3984 (NR_ 043840), and Streptomyces werraensis NBRC 13404 (NR_112390), all with 97% sequence identity
The duplicated ectoine biosynthetic gene clusters (BGCs) contribute to survivability under extreme conditions
Summary
Strain DH-12 exhibits broad-spectrum antibacterial activity toward Grampositive and Gram-negative pathogens. Genomea.asm.org 1 final draft genome assembly resulted in 13 contigs totaling 7,604,612 bp, with 147.3fold overall coverage and a GϩC content of 72.8%.
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