Abstract
Streptomyces sp. AVP053U2 is a marine bacterium isolated from Styela clava, a tunicate collected in Long Island Sound. Here, we report a draft genome for this bacterium, which was found to contain a high capacity for secondary metabolite production based on analysis and identification of numerous biosynthetic gene clusters.
Highlights
Actinomycetes from a variety of marine environments have demonstrated a strong potential for the production of biologically relevant secondary metabolites
Strains from the Streptomyces genus are known to be prolific producers of antibiotics and other biologically relevant secondary metabolites [1], with many of these molecules incorporating moieties derived from nonribosomal peptide synthetase (NRPS) and/or polyketide synthase (PKS) biosynthetic gene clusters [2]
AVP053U2 that contains a biosynthesis gene cluster responsible for the production of teleocidin B, a hybrid isoprenoid compound related to teleocidin A1, a toxic tumor promoter acting via PKC activation [4, 5]
Summary
Actinomycetes from a variety of marine environments have demonstrated a strong potential for the production of biologically relevant secondary metabolites. Strains from the Streptomyces genus are known to be prolific producers of antibiotics and other biologically relevant secondary metabolites [1], with many of these molecules incorporating moieties derived from nonribosomal peptide synthetase (NRPS) and/or polyketide synthase (PKS) biosynthetic gene clusters [2]. We report the genome sequence of a new strain of marinederived Streptomyces sp. AVP053U2 that contains a biosynthesis gene cluster responsible for the production of teleocidin B, a hybrid isoprenoid compound related to teleocidin A1, a toxic tumor promoter acting via PKC activation [4, 5].
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