Abstract
We report the draft genome sequence of Salmonella enterica serovar Typhi strain STH2370, isolated from a typhoid fever patient in Santiago, Chile. This clinical isolate has been used as the reference wild-type strain in numerous studies conducted in our laboratories during the last 15 years.
Highlights
We report the draft genome sequence of Salmonella enterica serovar Typhi strain STH2370, isolated from a typhoid fever patient in Santiago, Chile
Typhi STH2370, a clinical strain isolated in 1991 from a female typhoid fever patient admitted at the Hospital de Enfermedades Infecciosas Dr Lucio Córdova in Santiago, Chile
Our results indicate that the chromosome of strain STH2370 is composed of approximately 4,802,151 bp, with an average GϩC content of 52.1% and a total of 4,406 coding sequences
Summary
We report the draft genome sequence of Salmonella enterica serovar Typhi strain STH2370, isolated from a typhoid fever patient in Santiago, Chile. Salmonella enterica serovar Typhi is a human-restricted pathogen causing typhoid fever, a severe systemic disease with an estimated incidence of ~22 million cases per year worldwide (1, 2). Initial studies were conducted using the reference strain Ty2 (3, 4). This strain is attenuated in vivo and in vitro partly due to a frameshift mutation within the rpoS gene (5), which makes it less suitable for virulence assays.
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