Abstract
Coxiella burnetii Dog Utad, with a 2 008 938 bp genome is a strain isolated from a parturient dog responsible for a human familial outbreak of acute Q fever in Nova Scotia, Canada. Its genotype, determined by multispacer typing, is 21; the only one found in Canada that includes Q212, which causes endocarditis. Only 107 single nucleotide polymorphisms and 16 INDELs differed from Q212, suggesting a recent clonal radiation.
Highlights
Genotyping was performed on the strain using multi-spacer sequence typing (MST) [6], a technique based on the variability of ten intergenic sequences
A comparison of the COG categories showed that Dog Utad follows the same trend as the other available C. burnetii genomes, but with more similarities with CbuG_Q212, a genome previously deposited in GenBank corresponding to a strain from a Canadian man presenting with Q fever endocarditis and having the same genotype (MST21)
Two other strains from humans presenting with Q fever endocarditis, two from cats and one other from a dog from Canada were identified as MST21
Summary
Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever. Raoult1 1) Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Aix-Marseille Universite, Marseille, France and 2) Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
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