Abstract
ABSTRACTA colistin-resistant mcr-1-carrying Escherichia coli strain, RC2-007, was isolated from a swine farm in Mexico. This extraintestinal and uropathogenic strain of E. coli belongs to serotype O89:H9 and sequence type 744. Assembly and annotation resulted in a 4.9-Mb draft genome that revealed the presence of plasmid-mediated mcr-1-ISApI1 genes as part of a prophage.
Highlights
A colistin-resistant mcr-1-carrying Escherichia coli strain, RC2-007, was isolated from a swine farm in Mexico
The E. coli RC2-007 chromosome carried genes for serotype O89:H9 and sequence type 744, which interestingly was previously described in E. coli isolates obtained from gulls in Ushuaia, Argentina, that carried both the mcr-1 gene and CTX-M alleles [8]
The blaCTX-M-55 and mcr-1 genes are encoded, respectively, on conjugative 120-kb and nonconjugative 100-kb plasmids, this situation could have resulted from two indepen
Summary
A colistin-resistant mcr-1-carrying Escherichia coli strain, RC2-007, was isolated from a swine farm in Mexico. The whole-genome sequence was subjected to in silico analysis [4,5,6,7]. The following families of antibiotic resistance genes were identified: mcr-1 (polymyxin E); CTX-M-55 and TEM-1 (-lactams); aac[3]-IIa, strA-B, aadA5, and aadA12 (aminoglycosides); mph (macrolide); lnu (lincosamide); catA1 and florR (phenicol); sul1-2-3 (sulfonamide); tet-B (tetracycline); and dfrA17 (trimethoprim).
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