Abstract
Dracorhodin perchlorate (DP) is extracted from Dragon's blood, which is widely used in traditional Chinese medicine, especially in wound healing. The aim of this paper is to investigate the influence of DP ointment, which contained DP dissolved in DMSO and mixed with Vaseline, on cutaneous wound healing in Wistar rats. Forty Wistar rats were divided into two groups: control and DP groups. The skin on the back of each rat was punched with two full-thickness wounds and then treated with the corresponding drug. After 3, 7, 10, 14, and 21 days, four rats were sacrificed for immunological, biochemical, and histological analyses. Compared with the control treatment, DP could significantly promote wound closure. Histological and biochemical analyses of the skin biopsies also showed that DP regulated the expression of inflammatory responses by TNF-α and IL-β and by supporting wound tissue growth and collagen deposition. Western blot revealed that DP could also facilitate the expression of EGF and VEGF proteins. In conclusion, DP promotes wound healing.
Highlights
Wound healing is the repair of damaged skin tissue which consists of three stages, inflammation, proliferation, and remodeling [1, 2]
These stages occur at a specific time, but a number of factors such as wound type, severity, wound treatment will affect all phases of wound healing, which causes delays of wound healing [3]
Our results showed that Dracorhodin perchlorate (DP) affected the release of inflammatory cytokines
Summary
Wound healing is the repair of damaged skin tissue which consists of three stages, inflammation, proliferation, and remodeling [1, 2]. A wet and moist condition is needed to provide an optimum healing condition, which is regarded as a better method [4] Nowadays, many ways such as those that contain enzymes, polysaccharides of antibacterial ointment, growth factors, and other substances have been developed; a stable, lasting, and cheaper drug is an urgent problem because of the defects of these options [5]. Dragon’s blood has been used by different civilizations such as the Greeks, the Romans, and the Arabs It has several medicinal properties, such as wound healing, cicatrizant, immunomodulator, analgesic, antiulcer, antidiarrheal, antibacterial, antiviral, antihemorrhagic, antiinflammatory, antioxidant, mutagenic and antimutagenic, antitumor, anticancer, and cytotoxic effects [7]. Some experimental studies have shown that Dragon’s blood can promote the proliferation of fibroblasts and collagen formation and stimulate epithelium regeneration to promote wound healing
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