Abstract
Objective: To investigate the content and antioxidant activities of polyphenol, the correlation between polyphenol content and their antioxidant activities, and phytochemistry compositions of different extracts from marine sponge Aaptos suberitoides commonly found growing in Nhatrang bay, Vietnam orienting application into functional food and pharmacy.
 Methods: Evaluating the toxicity of antioxidant polyphenol powder preparing from the initial concentrated extract was by the adjusted Behrens Karber method and a correlation between polyphenol content and antioxidant activities basing on the Pearson coefficient in Excel. Separating antioxidant polyphenol content was base on solvents polarization of n-hexane, chloroform, ethanol, ethyl acetate and n-butanol which the quantification of polyphenol content and antioxidant activities, and preliminary phytochemical compositions qualitative.
 Results: Antioxidant polyphenol powder did not affect mice weight during the assay time of 28 d. Polyphenol content and antioxidant activities got the highest value at chloroform extract in comparison to other extracts, a significant difference (p<0.05) and strong correlation (R2>0.9). Polyphenol content (122.682 mg gallic acid equivalent ml-1), total antioxidant activity (368.183 mg ascorbic acid equivalent ml-1), reducing power activity (24.08 mg FeSO4 equivalent ml-1) and DPPH scavenging (72.48±1.54 %) were the highest values. Alkaloids, flavonoids, steroids, tannins and triterpenoids existed in initial methanol extract. Weakly polarized polyphenol content was 70.27% in comparison to initial methanol extract.
 Conclusion: Antioxidant polyphenol of sponge Aaptos suberitoides has the potential for application into the field of functional food and pharmaceuticals.
Highlights
Marine sponges are the basalmost clade of animals commonly found growing in died coral areas
Reports on biological activity substances of sponge growing in Vietnam waters mainly on alkaloids, terpenoids and steroids belong to different sponge species for instance Aaptos suberitoides [10, 11], Petrosia nigricans [12], Dysidea cinerea [13], Dysidea fragilis [14, 15], Smenospongia cerebriformis [16, 17], Haliclona oculata [18], and bioactivities of them were showed including the toxic [16, 18], anti-inflammatory [17], anti-bacterial [19], and anti-cancer activity [10, 11]
The results indicated that all different extracts of A. suberitoides were less diphenyl picrylhydrazyl (DPPH) scavenging profile than the extract of Sigmadocia carnosa, C. gorgonoides, Callyspongia sp. (86±1.0 %, 93.7±1.48 %, 94.8±0.83 %, respectively) [34]
Summary
Marine sponges are the basalmost clade of animals commonly found growing in died coral areas They have been considered as a drug treasure house containing great potential bioactive substance [1], for example, fatty acid, polyketides, pyrimidines [2], alkaloids [3, 4], polyphenols, tannins, flavonoids [5, 6]. Reports on biological activity substances of sponge growing in Vietnam waters mainly on alkaloids, terpenoids and steroids belong to different sponge species for instance Aaptos suberitoides [10, 11], Petrosia nigricans [12], Dysidea cinerea [13], Dysidea fragilis [14, 15], Smenospongia cerebriformis [16, 17], Haliclona oculata [18], and bioactivities of them were showed including the toxic [16, 18], anti-inflammatory [17], anti-bacterial [19], and anti-cancer activity [10, 11]. Aaptos suberitoides species commonly grow in Vietnam waters and many seas in the world
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