Dr. McMain Replies

Abstract

Back to table of contents Previous article Next article Letter to the EditorFull AccessDr. McMain RepliesShelley F. McMain, Ph.D.Shelley F. McMainSearch for more papers by this author, Ph.D.Published Online:1 Apr 2010https://doi.org/10.1176/appi.ajp.2009.09101532rAboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail To the Editor: We disagree with Dr. Case's view that when no difference is found between two potentially active treatments, confidence intervals would inform the question of whether a study demonstrates that the treatments are equivalent. Confidence intervals could not be used to answer the question of equivalence because our investigation was not designed or powered for an equivalence study. The lack of statistical significance, even with narrow confidence intervals, should not be used to conclude equivalence. It should be used only to conclude lack of difference. We agree that additional information, particularly confidence intervals, would have been helpful within our original report. Because of space limitations, we omitted this information. However, we have now provided the confidence intervals as a data supplement. Finally, upon examining our results, even if the study were much larger and had sufficient power to detect a difference, that difference would not have been clinically important.With respect to Dr. Case's question about group differences on baseline characteristics, our outcome analyses were based on global evaluation of efficacy and growth curve analyses and modeled for the possibility of between-group differences. No between-group differences at baseline were found on any variables.Toronto, Ont., CanadaThe author's disclosures accompany the original article. FiguresReferencesCited byDetailsCited ByJournal of Personality Disorders, Vol. 30, No. 1 Volume 167Issue 4 April 2010Pages 475-476 Metrics PDF download History Accepted 1 February 2010 Published online 1 April 2010 Published in print 1 April 2010