Abstract
Asteraceae species were widely applied in traditional medicines in Asian countries as sources of natural antioxidants and antimicrobial agents. This study aimed to evaluate DPPH-scavenging capacities and antimicrobial activities of nine Asteraceae species collected from Southern Vietnam. Antioxidant and antimicrobial activities were determined by standard protocols. Essential oils from Ageratum conyzoides, Helianthus annuus, and Artemisia vulgaris indicated significant inhibitory effects on Staphylococcus aureus and Candida spp. Crude extracts and fractions from Taraxacum officinale, Chrysanthemum morifolium, A. conyzoides, and Tagetes erecta showed inhibitory ability on at least one testing bacterial strains including S. aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. In a study on clinical isolates, ethyl acetate fraction from A. conyzoides flower displayed the most potent effect on uropathogenic E. coli and K. pneumoniae with MIC at 1.25–10 mg/ml and 5–12.5 mg/ml, respectively. DPPH-scavenging assay indicated that T. erecta extract had the lowest IC50 (17.280 μg/ml) and is 2.4 times higher than vitamin C (7.321 μg/ml). This study revealed that A. conyzoides has good potential against uropathogenic E. coli and K. pneumoniae, and therefore could be applied for prophylactic treatment of urinary infection.
Highlights
In recent years, antibiotic resistance has become more sophisticated, putting mankind into the postantibiotic era
We screened antimicrobial and antioxidant activities of ethanol extracts and essential oils from nine species of Asteraceae on 30 clinical strains causing urinary tract infection, collected from District 2 Hospital, Ho Chi Minh City, Vietnam. e target was seeking the best extract to apply for a healthcare serum to prevent recurrent urinary tract infections (UTIs). e antioxidant activity might be a protective factor for urinary tract epithelium to avoid the impact of oxidative stress
After pretreating and extracting herbal samples to obtain crude extracts and essential oils, we evaluated the antimicrobial effect by applying the diffusion method. e extracts which show activity were fractionated by n-hexane, chloroform, and ethyl acetate, respectively. e well-agar-diffusion method was used to determine the antimicrobial capacities of fractions
Summary
Antibiotic resistance has become more sophisticated, putting mankind into the postantibiotic era. In 2016, the first report about mcr-1 gene in a patient with urinary tract infections (UTIs) in Pennsylvania, the United States, was shown by Abbasi [5]. The causative agents of UTIs include uropathogenic E. coli, Klebsiella pneumoniae, Enterococcus spp., Staphylococcus saprophyticus, group B Streptococcus (GBS), Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida spp. There were many reports for antimicrobial and antioxidant effects of Asteraceae species, applications of these extracts in treating infectious diseases need an evaluation of pathogenic bacterial strains isolated from clinical specimens [11]. We screened antimicrobial and antioxidant activities of ethanol extracts and essential oils from nine species of Asteraceae on 30 clinical strains causing urinary tract infection, collected from District 2 Hospital, Ho Chi Minh City, Vietnam. We screened antimicrobial and antioxidant activities of ethanol extracts and essential oils from nine species of Asteraceae on 30 clinical strains causing urinary tract infection, collected from District 2 Hospital, Ho Chi Minh City, Vietnam. e target was seeking the best extract to apply for a healthcare serum to prevent recurrent UTIs. e antioxidant activity might be a protective factor for urinary tract epithelium to avoid the impact of oxidative stress
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