Dépistage des anomalies lipidiques chez les donneurs de sang

Abstract

The high incidence of cardio- or cerebro-vascular diseases is positively correlated with hyperlipoproteinemia. A large-scale screening of blood donor's populations could be used for the prevention of the atherogenic disease. Therefore lipoproteins electrophoresis on cellogel was compared with serum levels of triglycerides, cholesterol and lipids in 1184 blood donors (792 men, 392 women). The electrophoretic pattern was found abnormal in 32 cases (25 men, 7 women). It was a type IIb hyperlipoproteinemia, according to the classification of the World Health Organization. In these 32 subjects, serum triglycerides, cholesterol and lipids concentrations were significantly higher (p less than 0,001) than in 41 other donors with a normal electrophoretic pattern. A good positive correlation was found between high blood pressure or obesity or blood group O and abnormal electrophoretic pattern. Lipoproteins electrophoresis on cellogel appears to be a suitable test (easy, fast and economical) in large-scale screening for dyslipidemia in subjects over 40, or at least in cases of mild hypertension or obesity.