Abstract
Abstract Lipid domains play a critical role in signal transduction and transport across cell 
membranes. The formation of domains in "HLC" ternary lipid bilayers composed of high 
transition temperature (high-Tm) lipids, low-Tm lipids, and cholesterol (Chol) has been 
extensively studied as a raft-like system. Recently, experiments were performed to control 
the formation of submicron domains in LLC lipid bilayers containing low-Tm
phosphatidylethanolamine (PE), low-Tm phosphatidylcholine (PC), and Chol by 
manipulating the presence or absence of Chol. The formation of microdomains in this LLC 
mixture was replicated by dissipative particle dynamics (DPD) simulation. The results show 
that domain formation can be replicated.
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