DOZ047.02: Effect of prokinetics on gastric function in children with esophageal atresia and tracheoesophageal fistula (EA-TEF)

Abstract

Abstract Background To the aim of this study was to determine the effect of domperidone on gastric function in the EA-TEF cohort. Methods Five participants with previously demonstrated abnormal gastric myoelectrical activity and/or delayed gastric emptying on electrogastrography (EGG) and 13C-octanoic acid breath test (OBT), respectively, were recruited. These participants were treated with domperidone (0.2 mg/kg/dose twice a day), for a minimum of 2 weeks, and EGG and OBT investigations were repeated along with a validated PedsQL gastrointestinal symptom questionnaire. A baseline and follow-up ECG was done to check for potential QT interval prolongation. Results Mean gastric emptying half-time was135.4 minutes off therapy and 277.01 minutes on therapy (p = NS) while the mean gastric emptying coefficients were 3.34 and 3.25, respectively (p = NS). All five participants’ gastric myoelectrical activity on EGG remained abnormal. Although the mean percentage of gastric slow waves spent in normal frequency decreased by 1.65%, the post- prandial-to-resting power ratio increased by 8.452 (p = NS). Both parent- and child-reported overall PedsQL scores increased as did the child-reported PedsQL scores based on symptoms related to gastric function (p = NS). Conclusions Domperidone in standard doses did not result in significant change in gastric emptying in EA-TEF children with delayed gastric emptying. This may be due to abnormalities in gastric innervation, in children with EA-TEF. There was however an improvement in the power ratio on EGG. There was also improvement in the PedsQL scores. The lack of statistical significance may be due to our small sample size.