Abstract
The long-term morbidity of diabetes mellitus is characterized by increased oxidative stress and may involve the increased activity of matrix metalloproteinases (MMPs) in different tissues. The activities of matrix metalloproteinases (MMPs) may be increased and their endogenous inhibitors (TIMPs) decreased, in response to enhanced oxidative stress. This imbalance may contribute to the functional changes in the vasculature in diabetes. We therefore investigated the effect of the MMP inhibitor doxycycline treatment (Doxy, 15 mg/kg/day) on the contractile function of aorta from streptozotocin-induced (50 mg/kg) diabetic rats.
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