Abstract

The choice of empiric antimicrobial therapy for community-acquired respiratory infections is based on pathogens most likely to be encountered. β-Lactam antibiotics are commonly used for both upper and lower respiratory tract infections, and can, in most cases, be used as monotherapy against nonatypical pathogens. Doxycycline, a semisynthetic, second generation tetracycline, has a high degree of activity against all common respiratory pathogens including ampicillin-sensitive-resistant Haemophilus influenzae, β-lactamase-producing strains of Moraxella catarrhalis, and oral pigmented Bacteroides as well as organisms commonly causing atypical pneumonias, eg, Mycoplasma pneumoniae, Legionella pneumophila, or Chlamydia pneumoniae (TWAR agent).

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