Abstract

Objective: Major cause of failure in the treatment of advanced ovarian cancer is chemoresistance. Gold nanoparticles (AuNPs) are promising drug delivery systems for overcoming chemoresistance. Doxorubicin (DOX) is one of the representative cancer chemotherapeutic agents and is widely used by many researchers as a chemotherapy agent in the drug delivery system; however, there have been limited data on ovarian cancer research. The aim of our study was to compare cytotoxic effect between DOX and DOX-loaded oligonucleotides (ONTs) attached to gold nanoparticles (AuNPs), called DOA, on ovarian cancer cell lines.

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