Abstract
A middle aged male patient was diagnosed with B-cell non-Hodgkin's Lymphoma and treated with Rituximab, Doxorubicin, Vincristine, and Cyclophosphamide(R-CHOP) chemotherapy regimen for 6 months. Four months after the chemotherapy patient presented with symptoms of heart failure. There was no significant history of any cardiac disease in the past. Chest X-ray was done with showed enlarged cardiac silhouette. Echocardiography was done which revealed a dilated cardiomyopathy with severe left ventricular (LV) systolic dysfunction. Chest X ray before starting the chemotherapy had normal cardiac silhouette. Echocardiography reports before starting the chemotherapy were within normal limits with normal sized heart and normal ejection fraction. Patient was managed with optimal drugs and echocardiography was repeated after 1 year which showed an improved LV systolic function with ejection fraction of around 40%. This led to the diagnosis of Doxorubicin induced cardiomyopathy.
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