Doxepin sammenlignet med cimetidin i behandlingen av pasienter med endoskopisk påviste duodenalsår

Abstract

SummaryDoxepin reduces both basal and pentagastrin-stimulated output of gastric acid and pepsin in man. An open study was carried out, therefore, in 43 patients with endo-scopically confirmed duodenal ulcers to compare the effectiveness of doxepin (50 mg at night) or cimetidine (200+200+200+400 mg daily) for 6 weeks. Endoscopic examinations at 3 and 6 weeks were performed blindly. At 3 weeks, 60% of the patients treated with doxepin and 59% of those receiving cimetidine revealed endo-scopically healed ulcers. At 6 weeks, 84% of the patients treated with doxepin and 82 % of those receiving cimetidine were found to have endoscopically healed ulcers. No statistically significant differences in pain relief and assessments of patient well-being were found. Ulcer relapse occurred in 4 patients in the doxepin group and in 6 in the cimetidine group within 3 months. Thus, no significant differences in either healing frequency or pain relief were found in the two groups studied.