Abstract
Previous studies have suggested that altered miRNA expression in the placenta is associated with preeclampsia. The aim of this study was to investigate the expression of miR-424 in placental samples of severe preeclampsia (sPE) and uncomplicated pregnancy patients. miRNA was isolated from placentas obtained from 30 sPE patients and 30 healthy women. Quantitative real-time polymerase chain reaction was used to analyze the expression of miR-424. The prediction of target genes of miR-424 was performed using miRGen database. The function of these target genes was analyzed further by DAVID and Gorilla software. The expression of miR-424 was significantly lower in patients with sPE than in healthy controls. Changed expression of miR-424 in the case of pregnancy-related hypertensive disorders might affect the Wnt signaling pathway. These factors have a strong correlation with the development of PE. Expression of miR-424 in placenta was lower in patients with sPE, suggesting its role in the pathology of sPE.
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