Abstract
Downregulation of immunosuppressive environment in patients with chronic HBV hepatitis on maintained remission.
Highlights
Liver FoxP3 and PD1/PDL1 expression is down-regulated in chronic hepatitis B virus (HBV) hepatitis on maintained remission related to the degree of inflammation by Germanidis G, Argentou N, Hytiroglou P, Vassiliadis T, Patsiaoura K, Germenis AE, et al Front Immunol (2013) 4:207. doi:10. 3389/ fimmu.2013.00207
The HBV life cycle is not cytolytic to infected hepatocytes, and the liver damage is caused by a prolonged immune response induced by the expression of HBsAg on infected hepatocytes
CHB is managed with either interferon-based therapies that act by enhancing anti-viral immune responses or nucleos(t)ide analogs (NAs), such as entecavir, which inhibit HBV replication [3]
Summary
Liver FoxP3 and PD1/PDL1 expression is down-regulated in chronic HBV hepatitis on maintained remission related to the degree of inflammation by Germanidis G, Argentou N, Hytiroglou P, Vassiliadis T, Patsiaoura K, Germenis AE, et al Front Immunol (2013) 4:207. doi:10. 3389/ fimmu.2013.00207. A recent paper by Germanidis et al provides interesting insights into the relevance of these immunosuppressive pathways for treating chronic hepatitis B virus (HBV) hepatitis (CHB) [1]. The HBV life cycle is not cytolytic to infected hepatocytes, and the liver damage is caused by a prolonged immune response induced by the expression of HBsAg on infected hepatocytes.
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