Abstract
Chronic treatment with imipramine (15 mg/kg, twice daily for 14 days) induces a down-regulation of limbic D 1 receptors in rats but not in mice. In this mouse strain, both chronic and acute imipramine treatment have been shown to produce clear behavioral effects in the forced swim test. While the data presented here are consistent with previously reported findings in rats, they demonstrate that the down-regulation of D 1 receptors by chronic antidepressant treatment is species-specific. This phenomenon indicates that D 1 receptor down-regulation is not critical to the therapeutic mechanism of action of antidepressants.
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