Abstract
Gliomas are the most common primary tumors in the brain with poor prognosis. Previous studies have detected high expression of Cyclophilin A (CyPA) and CD147, respectively, in glioma. However, the correlation between their expressions and glioma prognosis remains unclear. Here, we investigated the expression of CyPA and CD147 in different types of glioma and characterized their relationships with clinical features, prognosis, and cell proliferation. Results showed that CyPA and CD147 expressions were elevated in higher grade gliomas. Moreover, the knockdown of CyPA and CD147 by RNA interference significantly induced cell express apoptosis biomarkers such as Annexin V and inhibited proliferation biomarkers like EdU in glioma cells. In summary, our findings revealed that high expression of CyPA and CD147 correlated with glioma grades. Moreover, downregulation of the Cyclophilin A/CD147 axis induces cell apoptosis and inhibits glioma aggressiveness. Those indicating CyPA and CD147 could be used as both potential predictive biomarkers and a potential therapeutic target.
Highlights
Gliomas are the most common primary tumors in the brain with a prevalence of between 5 and 10 cases per 100,000 people, accounting for 81% of central nervous system malignancies [1]
High Expression of Cyclophilin A (CyPA) and CD147 Is Associated with Glioma Grade, Histological Type, and Prognosis
In order to explore the role of CyPA and CD147 in glioma, we collect and analyze the mRNA expression and clinical information of patients with glioma from The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases
Summary
Gliomas are the most common primary tumors in the brain with a prevalence of between 5 and 10 cases per 100,000 people, accounting for 81% of central nervous system malignancies [1]. Gliomas are divided into four malignancy grades based on the World Health Organization classification [2], with prognosis dependent on tumor grade and histology. Cyclophilin A (CyPA), known as peptidylprolyl isomerase A (PPIA), is an enzyme encoded by the PPIA gene on chromosome 7. It is a member of the immunophilin family that belongs to the peptidyl-prolyl isomerase family. With the presence of reactive oxygen species, cells secrete CyPA to induce an inflammatory response and alleviate tissue injury [5]. Previous studies have demonstrated that extracellular CyPA promotes tumor proliferation, migration, and drug resistance in various studies [7,8,9]
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