Abstract
Background/aim Gastric cancer (GC) is one of the major causes of cancer mortality worldwide. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5’ and 3’ ends. They are very stable and abundant in eukaryotes. As there were no reported studies on the expression profiles of circular RNA ITCH (cir-ITCH) and circHIPK3in GC, in the current study, we aimed to delineate the expression profiles and clinicopathological relevance of these two circRNAs in GC tissues compared to their paired adjacent noncancerous tissues.Materials and methodsQuantitative real-time polymerase chain reaction was performed to evaluate cir_ITCH and circHIPK3 expression in 30 paired gastric cancer tissues. The clinicopathological relevance of these two circular RNAs’ expression levels with gastric cancer was further examined.ResultsOur results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts. Further analyses showed that cir_ITCH and circHIPK3 expression levels were related with numerous clinicopathological featuresof tumoral tissues.ConclusionCir_ITCH and circHIPK3 may have imperative roles in GC and serve in the future as potential prognostic biomarkers in GC.
Highlights
Gastric cancer (GC) is one of the unresolved causes of cancer mortality worldwide with a high rate of incidence and death [1,2]
Our results showed that the expression of cir_ITCH and circHIPK3 were significantly downregulated in GC tumoral tissues compared with their paired adjacent nonneoplastic counterparts
Further analyses showed that cir_ITCH and circHIPK3 expression levels were related with numerous clinicopathological features of tumoral tissues
Summary
Gastric cancer (GC) is one of the unresolved causes of cancer mortality worldwide with a high rate of incidence and death [1,2]. As a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) are formed by a covalent link between 5’ and 3’ ends [6,7,8]. They are very stable and abundant in eukaryotes [9,10,11]. Recent reports show that circRNAs can function as microRNA sponges, regulate gene expression, linear RNA transcription and protein production [7]. Further functional studies showed that cir-ITCH can act as microRNA sponge increasing the level of parental gene, ITCH [15]
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