Abstract
<p align="center"><strong>Abstract</strong></p><p><strong>Background:</strong> To find the effect of Hyperbaric Oxygen Therapy in the myometrium expressions of ICAM1 from pregnant Rattus norvegicus infected with Tachyzoite <em>Toxoplasma gondii.</em></p><p><strong>Material and Methods :</strong></p><p>This is an experimental study with a post-test only design on 37 pregnant <em>Rattus norvegicus</em> <em>Sprague Dawley</em>, then the rats were divided into 4 groups. The HBOT group A is pregnant rats infected with tachyzoite received therapy 10 sessions of HBOT 2.4 ATA in 3x30 minutes; the group B is Pregnant only and get no HBOT; the group C is Pregnant and infected with <em>tachyzoite T.gondii</em> but not received HBOT, and the group D is normal pregnant rats. Each infected pregnant rats were given a 10<sup>3 </sup>Tachyzoite of <em>Toxoplasma gondii</em> via intraperitoneal. Examinations of ICAM1 expressions were performed on day-5 after HBOT (twice a day). Rats were killed and the myometrial ICAM1 levels were measured with Immunohistochemistry examination. All data were analyzed with the ANOVA test with SPSS 21 Program.<strong></strong></p><p><strong>Results: </strong>The results show that Hyperbaric Oxygen Therapy can downregulate ICAM1 in the administered of HBO 2.4 ATA for 3x30 minutes in 10 sessions over 5 days of therapy.</p><p><strong>Conclusion:</strong> The study concludes that HBOT can downregulate the expressions of ICAM1 in the myometrium, in the provision of HBO 2.4 ATA for 3x30 minutes in 10 sessions.</p>
Highlights
Tachyzoite T. gondii infection can harm the fetus and often causes abortion and congenital disability (McAuley et al, 2014)
The Hyperbaric Oxygen Therapy (HBOT) group A is pregnant rats infected with tachyzoite received therapy 10 sessions of HBOT 2.4 ATA in 3x30 minutes; the group B is Pregnant, not infected with tachyzoite and get HBOT; the group C is Pregnant and infected with tachyzoite T.gondii but not received HBOT; and group D consisted of normal pregnant rats that were not infected with tachyzoite and were not given HBOT
Gondii without obtaining therapy or group C experienced a significant increase of 8,525 while in group A HBOT expression could decrease ICAM1 expression in myometrium
Summary
Tachyzoite T. gondii infection can harm the fetus and often causes abortion and congenital disability (McAuley et al, 2014). T. gondii infection can cause an increase in ICAM1 and 5-HT and the migration of mast cells to the site of infection. This results in decreased submucosal thickness and impaired extra cellular matrix formation (ECM) over a period of 12-24 hours after infection (Pastre et al, 2019). HBOT can reduce ICAM1 formation (Uzun Gunalp et al, 2010; John et al, 2008). ICAM1 in pregnancy with Toxoplasma gondii infection can increase the number of Tachyzoite infections into the placenta and fetus. Hyperbaric Oxygen Therapy (HBOT) is often used and is safe in the treatment of anemia in pregnancy, besides HBOT can reduce ICAM1 through the induction of eNOS.
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