Abstract
The mechanical performance of articular cartilage and its optimization for load-bearing function is determined by the biochemical assembly of the extracellular matrix (ECM) [Mow, 1992]. Both magnitude and type of mechanical loading have the potential to alter ECM protein synthesis of collagen II and cartilage oligomeric matrix protein (COMP), two major network stabilizing proteins, in a sitespecific manner [Kiviranta, 1988, Skioldebrand, 2010]. Downhill running as a natural form of eccentric exercise [Butterfield, 2005] has been shown to induce higher knee joint loadings compared to level running [Kuster, 1995]. However, its influence on articular cartilage assembly and mechanical properties has not yet been studied. In the present study we examined the effect of different running modes (downhill vs. level) on site-specific cartilage adaptation.
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