Down Sendromlu hastalarda subklinik hipotiroidizm ve hematolojik parametreler arasındaki ilişki

Abstract

Introduction: Down syndrome (DS) which is defined as trisomy 21 is the most common chromosomal defect characterized by mental retardation, hypotonia, dysmorphic facial features, and other distinctive phenotypic characteristics. The prevalence of thyroid disorders in DS is 3% and is significantly higher than in the normal population. In this study we aimed to investigate hematologic parameters of children with DS who had and hadn’t subclinical hypothyroidism and compare them with healthy controls. Methods: This study included 184 patients who were followed up with genetically diagnosed DS. Complete blood count, levels of serum electrolytes, glucose, urea, liver function tests, thyroid function tests were reviewed. Results: 102 (55.4%) of the patients with DS were male and 82 (44.6%) were female. Mean age was 6.2 ± 4.0 years. Control group was constituted of outpatient healthy children. White blood cell count, hemoglobin, hematocrit, and neutrophil counts were found to be significantly lower in patients with DS. Platelet count and plateletcrit levels were found to be higher and platelet distribution width was lower in patients with DS than in the control group. Conclusion: We found significant differences among hematological parameters in patients with DS. Subclinical hypothyroidism influences red blood cell distribution width, platelet count and MPV. Knowing the incidence and severity of hematologic abnormalities in patients with DS will be beneficial during follow-up in clinical practice.