Down Regulation of Sirtuins in the Serum of Frail Elderly as Compared to Non-frail Elderly: Promising Diagnostic Protein Marker for Frailty

Abstract

Ageing, the accumulation of damage to molecules, cells and tissues over a lifetime, often leads to frailty and malfunction. The functional decline, disability and frailty are the common conditions of the geriatric syndromes. The syndrome of frailty is complex and still lack of a standard definition. As the exact cause of frailty of older people is not known, it will be a great challenge to develop biomarker that characterize the frailty syndrome and help in clinical diagnosis. This will provide a new ways of defining disability outcomes in epidemiological studies of the elderly. Based on above evidences, this study attempts to devise a new tool and develop sirtuins as a biological marker for frailty in old age. Most recent study has observed the low expression of sirtuin in old age. This study evaluated the sirtuin in frail person and compared with non-frail elderly person. The concentration of SIRT1, SIRT2 and SIRT3 were evaluated by Surface Plasmon resonance technology. In frail elderly the declining level of SIRT1, SIRT2 and SIRT3 were observed as compared to non-frail elderly. The pronounced declining level of sirtuin in frail elderly can provides an opportunity to develop this protein as a predictive marker in early stages of frailty with suitable cut off values.