Abstract
Down-regulation of ER-α36 mRNA in serum exosomes of the patients with hepatocellular carcinoma.
Highlights
The results showed that ER-α66 and ER-α36 were expressed in both hepatocellular carcinoma (HCC) and adjacent normal tissue, and located in the cytoplasm and cell membrane of hepatocytes and HCC cells (Figure 1A)
Results showed that plasma estrogen levels were found to be significantly elevated in liver cirrhosis (LC) patients compared with that in CHB patients, and significantly lower in the HCC patients compared with the LC patients (P < .05) (Figure 1B), suggesting that estrogen may be involved in the regulation of the development of HCC
The results showed the area under the curve (AUC) of ER-α66 mRNA was 0.876 (P = .003, 95% CI = 0.732-1.000) and that of ER-α36 mRNA was 0.842 (P = .002, 95% CI 0.669-1.000), indicating that mRNAs of ER-α66 and ER-α36 show good accuracy for the diagnostic of HCC and could be effectively used to distinguish HCC from adjacent tissue (Figure 2I)
Summary
We report our study on the expression pattern of estrogen and its receptor variants in serum exosomes of HCC, and provide insightful information for the diagnosis of human HCC. Results showed that plasma estrogen levels were found to be significantly elevated in LC patients compared with that in CHB patients, and significantly lower in the HCC patients compared with the LC patients (P < .05) (Figure 1B), suggesting that estrogen may be involved in the regulation of the development of HCC.
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