Down-Regulation of Akt Expression Plays an Important Role in Embryonic Arrest

Abstract

Embryonic arrest patients are increasing in worldwide, but its reason remains unknown. Our objective is to detect the Akt expression in the decidual tissues and chorionic tissues of embryonic arrest patients and to explore if it play important role in embryonic arrest. The decidual tissues and chorionic tissues of 18 pregnant women with a second embryonic arrest and 20 pregnant women with a first embryonic arrest were collected, and 18 pregnant health women were used as controls group. Next immunohistochemistry was adopted to detect the expression of Akt expression in decidual tissues and chorionic tissues. Compared to control group, the expression of Akt protein in the decidual tissues and chorionic tissues of the one-time group and two-time group both were significantly reduced (p <0.05). In addition, we summarize and analyze the gene knockout mice phenotype of PI3K/Akt pathway, these literatures support our results. And Akt1, Akt2, and Akt3 exist a mutual compensation effect. Interestingly, Akt1 knockout directly affects the development of the fetus. In conclusion, the PI3K/Akt signaling pathway is involved in the process of embryonic development and is closely related to embryonic arrest.