Abstract
Doubling the Dose
Highlights
Maintaining the correct dosage of chromosomes is crucial for a cell to function properly
One copy of each X becomes densely packed and shut down, normalizing their X gene expression levels to the half dose of males, while in the nematode worm, both female X chromosomes are turned down half way
On in developing embryos, not all the proteins needed for the Male Specific Lethal’’ (MSL) complex are present, meaning that there is a period during which the canonical dosage compensation machinery in inactive
Summary
Maintaining the correct dosage of chromosomes is crucial for a cell to function properly. In this issue of PLoS Biology, Susan Lott and colleagues use new advances in sequencing to show for the first time that, does dosage compensation occur earlier in developing embryos than had previously been thought, but that it does so by a novel mechanism.
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