Abstract
Objective to investigate the effect of Huoxue Jiedu Jiangtang Recipe (HJJR) on cardiac remodeling and function prognosis in diabetic patients complicated with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), and to explore its possible mechanism. Methods 92 diabetic patients with CHD who had received PCI therapy, were equally randomized into the treatment group (46) and the control group (46) from January 2016 to August 2016. The control group were given standardized western medicine, while treatment group received HJJR besides standardized treatment. The treating course were 2 months. Before and after treatment, the left ventricular morphology index [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic ventricular septal thickness (LVEST)] and the cardiac function data [stroke volume (SV), left ventricular fractional shortening (FS), the cardiac index (CI), cardiac output (CO), maximum blood flow velocity of early diastolic/ atrium late diastolic (E/A), left ventricle ejection fraction (EF)] were detected with echocardiography. The serum levels of C-reactive protein (CRP), tumor necrosis factor-a (TNF-α), interleukin-6 (IL-6) and Angiotensin II (Ang II) were tested with enzyme linked immunosorbent assay (ELISA), and the clinical efficacy and 5-year survival rate were evaluated. Results The total clinical effective rate and 5-year survival ratio in treatment group were higher than those in control group (P<0.05). Serum inflammatory mediators (CRP, IL-6, TNF-α) and Ang II decreased more than that in the control group (all P<0.05); And in treatment group, the left ventricular morphology index (LVESD, LVEDD) decreased more than that in the control group, while the cardiac function indexes (∆ FS, CO, CI, SV, LVEF, E/A) were increased more in treatment group. Conclusion HJJR can hold back the deterioration of heart restructure, improve heart function, ameliorate prognosis and prolong living in diabetic CHD after PCI, and its partial therapeutic effects might come from its reducing the level of Ang II and anti-inflammatory function.
Highlights
Since 1977, when Swiss scientist Cruentzig succeeded in opening the narrow coronary artery by percutaneous coronary intervention (PCI) for the first time, creating a new era in the medical history for treating coronary heart disease (CHD), PCI has made rapid development, becoming an effective treatment, and widely applied to the reperfusion treatment of CHD
This study found that, in diabetic patients with acute coronary syndrome after PCI, basis on conventional western medicine treatment plus Huoxue Jiedu Jiangtang Recipe (HJJR), the left ventricular morphology index left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were significantly reduced, while the cardiac function index left ventricle ejection fraction (LVEF), E / A, stroke volume (SV), cardiac output (CO), cardiac index (CI) and ∆ fractional shortening (FS) were significantly increased; the levels of inflammatory mediators IL-6, C-reactive protein (CRP), TNF-α and serum Angiotensin II (Ang II) were decreased
The results indicate that, by alleviating the inflammatory response caused by oxidative stress of diabetes mellitus, inhibiting the RASS system, HJJR can improve ventricular remodeling, enhance heart function, improve the quality of life and prognosis, with good patient compliance and less adverse reactions
Summary
Since 1977, when Swiss scientist Cruentzig succeeded in opening the narrow coronary artery by percutaneous coronary intervention (PCI) for the first time, creating a new era in the medical history for treating coronary heart disease (CHD), PCI has made rapid development, becoming an effective treatment, and widely applied to the reperfusion treatment of CHD. The severity of coronary artery disease is related to a variety of risk factors, among which diabetes is the most significant independent risk factor. CHD with diabetes usually presents multiple stenosis and often coexist with microvascular disease [1]. Non-diabetic patients have a compensatory dilative movement in the non-infarcted vascular after the onset of myocardial infarction, while in diabetic patients, due to multiple vascular and myocardial microvascular lesions, the vascular compensatory movement is weakened [2]. The important goal of heart failure treatment is to prevent and delay the development of
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
