Abstract
A composite particle with a double-coating layer consisting of silica (0.3 μm), titania (0.017 μm) and polyethylene beads (13.1 μm) was prepared by a dry impact blending method. The composite particle was employed as a complex stationary phase for high-performance liquid chromatography. Forming the surface double layer caused a change in the surface acidity of the oxides; as a result, the complex stationary phase enhanced the chromatographic retention behavior depending on the ionic interaction. Therefore, the complex stationary phase demonstrates the properties of a novel stationary phase rather than those of a mixture of two stationary phases. By using the multiple retention mechanisms, the separation of some basic drugs and the simultaneous analysis of acids and bases were performed.
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