Abstract
The outcome of viral infection is largely determined by the types of cells the virus invades and the steps of viral replication which the cell will support. Under permissive conditions, high levels of viral gene expression in cells essential to the host may result in serious illness or death. On the other hand, persistent infections are the result of restricted gene expression which may allow the host cell to survive and the virus to escape detection and destruction by the host’s immune surveillance system. We have devised two double-label single cell methods to define the cellular tropisms of viruses and their genetic programs in the infected cell. This chapter contains descriptions of these methods integrated with illustrations of applications to studies of viral pathogenesis.KeywordsHuman Immunodeficiency VirusGlial Fibrillary Acidic ProteinColor IllustrationMagenta ColorVisna VirusThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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