Double-hit high-grade B-cell lymphoma with aberrant T-cell phenotype

Abstract

Abstract Aberrant T-cell phenotype or aberrant B-cell phenotype in B-cell non-Hodgkin’s lymphoma or T-cell non-Hodgkin’s lymphoma, respectively, are uncommon phenomenon and a diagnostic challenge. Multiple T-cell antigen, including CD3 expression in large B-cell lymphomas, which is considered a specific marker for T cells, is extremely rare and have scattered instances in the literature; however, none of those showed myc and bcl2 rearrangement. This is a case of stage IV NHL, previously diagnosed as T-cell NHL, which on detailed immunohistochemical and molecular diagnostic workup, later was confirmed as “Double hit” B-cell lymphoma with aberrant T-cell phenotype. With the 1st ever-reported case, we wish to bring into the notice of such aberrancy so as to not misdiagnose or wrongly classify high-grade lymphomas.