Double-Edged Sword of Tumour Suppressor Genes in Schizophrenia.

Chuanjun Zhuo,Chuanjun Zhuo,Chuanjun Zhuo,Chuanjun Zhuo,Chuanjun Zhuo,Min Chen,Dawei Wang,Li Zhang,Jie Li,Jie Li,Shen Li,Shen Li,Shen Li,Ce Chen,Feng Ji,Chunhua Zhou,Chunhua Zhou,Hongjun Tian,Hongjun Tian,Chuanxin Liu

doi:10.3389/fnmol.2019.00001

Abstract

Schizophrenia (SCZ) is a common psychiatric disorder with polygenetic pathogenesis. Among the many identified candidate genes and loci, the group of tumour suppressor genes has drawn our interest. In this mini-review article, we describe evidence of a correlation between major tumour suppressor genes and SCZ development. Genetic mutations ranging from single nucleotide polymorphisms to large structural alterations have been found in tumour-related genes in patients with SCZ. Epigenetic mechanisms, including DNA methylation/acetylation and microRNA regulation of tumour suppressor genes, have also been implicated in SCZ. Beyond genetic correlations, we hope to establish causal relationships between tumour suppressor gene function and SCZ risk. Accumulating evidence shows that tumour suppressor genes may mediate cell survival and neural development, both of which contribute to SCZ aetiology. Moreover, converging intracellular signalling pathways indicate a role of tumour suppressor genes in SCZ pathogenesis. Tumour suppressor gene function may mediate a direct link between neural development and function and psychiatric disorders, including SCZ. A deeper understanding of how neural cell development is affected by tumour suppressors may lead to improved anti-psychotic drugs.

Highlights

Reviewed by: Ming Li, Kunming Institute of Zoology, China Lara Sabrina Carroll, University of Utah, United States
The authors argued that the elevated cancer risk in patients with SCZ was likely attributable to their unhealthy lifestyles, whereas the lower-than-normal risk in unaffected siblings might reflect the protective effects of increased tumour suppressor gene expression uncompromised by unhealthy lifestyle changes
We have summarised the recent major progress in understanding the roles of tumour suppressor genes in SCZ pathogenesis and discussed potential underlying cellular and molecular mechanisms

Summary

Introduction

In this mini-review article, we describe evidence of a correlation between major tumour suppressor genes and SCZ development. Tumour suppressor gene function may mediate a direct link between neural development and function and psychiatric disorders, including SCZ. Gene Association Studies Linking TP53 and Wnt Pathway Genes to SCZ

Results

Conclusion