Double dissociation of passive avoidance and milk maze performance deficits with discrete lesions of substantia innominata or globus pallidus of rats

Abstract

In three experiments, small bilateral lesions of the substantia innominata (SI), globus pallidus (GP) and central nucleus of the amygdala (ACe) produced deficits in passive avoidance of drinking (dPA) or escape performance in a milk maze (MM). Severe deficits in dPA were produced by electrolytic lesions in lateral SI or rostral ACe, and by electrolytic or ibotenic acid lesions in the heart of the SI. Such lesions produced no effects on MM performance. Lesions of the rostral SI produced no, or mild, deficits in dPA and MM performance. However, lesions of the rostral GP produced an extreme deficit in MM performance but not dPA. The milder MM deficits produced by rSI lesions appeared to reflect a spatial navigation deficit, while the more severe impairment produced by rGP lesions appeared to represent a broader disruption of instrumental behavior. SI lesions also produced a temporary cessation of drinking and a chronic decrease in body weight, both of which were associated with impaired oromotor function. Eating and drinking deficits were less severe when lesions were more lateral or rostral in SI, and absent with lesions in rostral GP or amygdala. The most important finding, however, was a double dissociation of MM performance deficits following rostral GP lesions versus passive avoidance deficits produced by SI lesions.